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8. Anti -alpha Actinin Rabbit pAb, 100ul $450
$450.00
In Stock
Description
Product Information
| Description | alpha Actinin rabbit polyclonal antibody |
| Protein full name | Alpha-actinin-1 |
| Synonyms | Alpha-actinin cytoskeletal isoform, F-actin cross-linking protein, actinin, Non-muscle alpha-actinin-1, ACTN1, actinin 1 smooth muscle, Actn1a, BDPLT15, I79_004057 |
| Immunogen | Recombinant protein corresponding to Mouse α-actinin1 |
| Isotype | IgG |
| Purity | Affinity purification |
| Predicted MW. | 103 kDa |
| Observed MW. | 103 kDa |
| Uniprot ID | Q7TPR4, P12814, Q9Z1P2 |
Applications
| Applications | Species | Dilution | Positive Sample |
| WB | Human, Mouse, Rat | 1: 2000-1: 4000 | lung, stomach, colon, hysteromyoma |
Background
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found alongmicrofilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene.
Images
 |
Western blot analysis of a-Actinin (GB11230) at dilution of 1: 2000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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